The .gov means its official.Federal government websites often end in .gov or .mil. Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) or 1.1% (11 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Do not use unless the solution is clear and seal intact. The pH is 5.7 (4.5 to 7.0). Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, . Any transfer and handling, such as loading of the lyophilizer, should take place under primary barriers, such as laminar flow hoods under which the vials were filled. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium. You'll need an alcohol wipe, your bacteriostatic water and HCG vials, your reconstitution syringe and needle, and a Sharps container for safe disposal. Due to the potential for toxicity, solutions containing benzyl alcohol should not be used in neonates. Nothing really. HGH Mixing Reconstitution 1. This can come into play when preparing for traveling, budgeting monthly expenses and storage. Not only is this inefficient, but you may come across low-quality products from inferior manufacturers. This bacteriostat is usually 0.9% benzyl alcohol. pose a threat of fluid overload except possibly in very small infants. ; "Manufacturing Economies and Product Improvement Through Advanced Freeze Drying Techniques"; Reprint of talk to Annual Meeting of Parenteral Drug Assn. Once a vial of bacteriostatic water is opened, the benzyl alcohol will usually prevent the growth of bacteria for up to 28 days. You can email the site owner to let them know you were blocked. Inspect reconstituted (diluted or dissolved) drugs for clarity (if soluble) and freedom from unexpected precipitation or discoloration prior to administration. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. 1. : the action of reconstituting or state of being reconstituted. An official website of the United States government, : When necessary, the pH of each formula was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7 to 8 and the tonicities are, for the 40 mg per mL . May contain hydrochloric acid for pH adjustment. Peptide reconstitution is a complicated and confusing process for many. Reconstitution Solution versus Bacteriostatic Water I need to rehydrate some BPC, but when I look for bacteriostatic water on Amazon, it takes me directly to "reconstitution solution." If both items are the same (benzyl alcohol bacteriostatic solutions) why use the different name? Air oxidation is yet another threat to the efficacy of the peptide, especially some peptides having amino acids such as free cysteine and tryptophan. Note that sodium chloride water shouldnt be used as it may result in precipitates. Gather the following: alcohol swabs, bacteriostatic water, peptide powder, and a sterile syringe. There is literally no other option. Provisions for sterilizing the inert gas or air supply lines. It is considered an ideal sterile solution due to its low toxicity and minimal interference with drug effectiveness. Typically available as lyophilized powders to maintain purity and integrity, peptides require reconstitution before injection [12]. As I mentioned at the start, the sterile water vial doesnt contain benzyl alcohol which makes it unfavorable for storage. When reconstituted with Bacteriostatic Water for Injection, USP, the resulting solution must be used within 7 days. A verification code will be sent to you. The container can be re-entered multiple times (usually by a sterile needle) and the benzyl alcohol is added to ensure that bacteria does not grow in the water as diluting medications with tainted water can have some severe consequences. The starter set has all you need to get going, including the following: If you want a little more, check out the premium kit: Qualified handlers are sure to enjoy this top online source for research materials. The pH is 5.7 (4.5 to 7.0). Bacteriostatic 0.9% Sodium Chloride (NaCl) Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. The filling of vials that are to be lyophilized has some problems that are somewhat unique. It is only used for injections such as intravenous, intramuscular and subcutaneous. While you can go on to use the conventionally manual way to reconstitute peptides, it gets a whole lot easier to use the reconstitution calculator, and get the right dosage! The safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers. Bacteriostatic waters preservative content prevents contamination for multiple doses, while sterile water may be contaminated after one use. Because of the benzyl alcohol contained in Bacteriostatic Water for Injection, USP, when doses greater than . It would ideally be either 0.3ml, 0.5ml or 1ml syringe. Correctly reconstituting peptides is essential in their effectiveness. Wir verstehen die Bedeutung der Kunden auf dem richtigen Weg zum Erfolg bringen, und wir sind bereit, mit ihnen der Planung in allen Bereichen zu arbeiten. You use Bac.Water to backload the pin. It is also not known whether Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection containing additives can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Read the full review on BPC 157 only at Muscle and Brawn. Made with the organic preservative benzyl alcohol, this solution resists contamination to enable multiple doses per vial. Although rarely, but they can occur, those side effects are more related to the drug that is dissolved in the bacteriostatic water. They can manage our circadian rhythms, regulate growth hormones, help with weight loss, and even make us look younger. Other side effects can include low blood sodium also known as hyponatremia, fluid overload, allergic reactions (tightness in the chest, swelling of the mouth, face, and lips) fever, redness at the site of injection as well as electrolyte imbalance. For those of you thinking about the volume of water, 1ml is usually enough for all the peptides available in the market. The site is secure. Data are unavailable on the toxicity of other preservatives in this age group. You will learn its various applications, how it differs from sterile water, and your best online source to buy bacteriostatic water kits. Bacteriostatic water is water with benzyl alcohol. Our focus is to exclusively link to peer-reviewed studies found on respected websites, like PubMed. Bacteriostatic water is a sterile form of water that has been brought to a pH between 4.5 to 7.0. Daptomycin RF has a longer in-use shelf period although times vary based on dosage form (vial, IV bag, or syringe) and diluent used. Would love your thoughts, please comment. Cloudflare Ray ID: 7c0dd6108cb23fde I need to rehydrate some BPC, but when I look for bacteriostatic water on Amazon, it takes me directly to "reconstitution solution." 3, pp. Our content is continually monitored by an internal peer-review process to ensure accuracy. I recommend using bacteriostatic water since that's what the peptide vendors sell and recommend. Both bacteriostatic water and sterile water are not used for straight injections, they have to be diluted with a drug or solvent. Due to the potential toxicity of benzyl alcohol in neonates, solutions containing benzyl alcohol must not be used in this patient population. However, this method requires special equipment and expertise. Based on 31 documents. In the event these should occur, re-evaluate the patient and institute appropriate corrective measures. This significantly reduces the risk of infection [, It is an efficient solvent and presents minimal interaction with most medications [, Apart from medications, bacteriostatic water is also indicated for the reconstitution and injection of therapeutic research peptides and hormones [, Suitable injection routes are determined by the type of solute, the recipients needs, and target rates of diffusion and metabolization. The contents of Peptides.org are intended exclusively for qualified researchers. It also is prepared with a bacteriostat, a compound used to prevent any bacterial growth. Contraindications for bacteriostatic water injections include newborn babies and cerebrospinal injections [2, 8]. Because they are antibiotics, low bioburden of these formulations would be expected at the time of batching. These lyophilizers can only have their inside surfaces wiped with a chemical agent that may be a sterilant. Bacteriostatic water and sterile water are essentially used for the same function which is to dissolve the drugs/medications for injecting purposes. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Parenteral preparations with benzyl alcohol should not be used for fluid replacement. Please refer to the WARNINGS Avoid repeated freeze-thaw cycles: It is essential to avoid repeated freeze-thaw cycles, as they can cause damage to the peptide and decrease its stability and activity. Buckle LLC reserves the right to remove any of Your Content from this Website at any time without notice. If you are a peptide researcher or laboratory professional, you can safely enjoy the benefits of bacteriostatic water with proper use. Other than the content you own, under these Terms, Buckle LLC and/or its licensors own all the intellectual property rights and materials contained in this Website. Plus, peptide solutions made with bacteriostatic water resist contamination. You can email the site owner to let them know you were blocked. Bacteriostatic 0.9% Sodium Chloride Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. 62.5 mg/mL, 3.2 mL b. Most peptides that you will see are often sold as lyophilized peptides which means that (freeze-dried) powder form. Benzyl alcohol, a preservative in Bacteriostatic Water for Injection, USP has been associated with toxicity in neonates. You should never inject bacteriostatic water without mixing in any medications because the benzyl alcohol in it causes the red blood cell lysis. See WARNINGS, PRECAUTIONS and our They quickly get ruined by heating, even room temperatures, and vigorous movement. We do the complete research and follow standards before starting the manufacturing process. We spent 20 hours of research finding optimal recommended dosages for every popular peptide. Prior to buying anything, check that it is compliant where you live with your current government laws. It is a copolymer of ethylene and propylene. Because of the potential toxicities associated with Bacteriostatic Water for Injection, many hospitals only utilize WFI. Methylprednisolone sodium succinate has the same . FDA rev date: 6/15/2000. Bacteriostatic Water for Injection, USP must be made approximately isotonic prior to use. When it comes to reconstituting peptides, there is a common question of whether bacteriostatic water is the same as sterile water. Use only as a diluent or solvent. ZOMACTON 10 mg reconstituted with bacteriostatic water for injection containing 0.33% metacresol should not be used if the patient is allergic to metacresol. IMPORTANT - Use only Bacteriostatic Water for Injection with Benzyl Alcohol .
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